DescriptionAn in-depth report on the causes, diagnosis, treatment, and prevention of kidney stones.
Alternative NamesCalcium Stones; Extracoporeal Shock Wave Lithotripsy; Lithotripsy; Nephrolithiasis; Oxalates; Uric Acid
All individuals who have experienced kidney stones should take some specific preventive measures to prevent recurrence. The following are some general observations:
Because kidney stone types may require specific dietary changes, patients should work with their physicians to develop an individualized plan. It should be stressed that nutritional considerations are very important in preventing recurrence, and patients should be vigilant in complying with the proper diet.
Fluids (Water, Juice, and Other Beverages)
Good voiding habits, particularly frequent urination, is important. Therefore, of all the preventive recommendations, drinking enough fluid is the most important guideline for people with any type of kidney stones.
In all cases, more fluid is needed after exertion and during times of stress. If fluid intake is sufficient, the urine should be pale and almost watery, not dark and yellow.
Water. Although water is best, it may vary depending on its source. Variations in water itself may have different impacts. One study reported that drinking hard tap water increased urinary calcium concentration by 50% compared to soft bottled water. On the other hand, mineral water containing both calcium and magnesium may reduce several risk factors for both calcium and uric acid stone formation.
Juices and Specific Effects. Other beverages have various positive or negative effects, depending on the type of stone:
Other Beverages and Their Effects on Stone Formation.
Low-Salt and Low-Protein Diets
In a long-term 2002 study of men with calcium oxalate stones and high levels of urinary calcium, a low-sodium, low-protein diet containing normal levels of calcium dramatically reduced the recurrence of stones compared to a diet that was simply low in calcium.
Salt Restriction. Because salt intake increases the amount of calcium in urine, patients with calcium stones should restrict their sodium intake. Sodium may also elevate levels of urate, the crystalline substance that can trigger formation of recurrent calcium oxalate stones. Although the relative contribution of sodium restriction in this and other studies has not been confirmed, some researchers believe that restricting sodium along with increasing fluid intake is the most important dietary measure for preventing stones.
Protein Restriction. Protein increases uric acid, calcium, and oxalates in the urine and reduces citrate. Diets high in protein, particularly meat protein, have been consistently associated with kidney stones. (Meat protein has a higher sulfur content and generates more acid than vegetable protein.) A 2002 trial of those following a high-protein, low-carbohydrate diet, popularized in such weight-loss regimens as the Atkins diet, for example, found dramatically increased levels of urinary uric acid and calcium after just several weeks. These effects put patients at higher risk not just of kidney stones but possibly of osteoporosis as well. According to Swiss studies, about a third of people at risk for calcium stones may have a sensitivity to meat proteins that cause mild hyperoxaluria.
Whether restricting meat protein alone has any protective value without restricting sodium as well is unknown. Most studies to date have found no difference in stone development between people with low and normal meat protein diets over four years. A 2000 study reported that only dramatic reductions in meat protein had any preventive effect against stone recurrence.
Although the precise role of dietary protein in kidney stones needs further elucidation, it is reasonable for everyone to consume meat protein in moderation. People with struvite stones, who need to reduce phosphates in their diets, should also cut down on proteins.
Role of Calcium
Calcium from Foods. It has been fairly well established that dietary calcium (such as in dairy products) is actually protective against many cases of calcium oxalate stones. Large studies of both men and women found that those with the highest intake of calcium from foods had a much lower risk for stones than those who had little calcium in their diets. And a rigorous five-year 2002 study investigated men with high urinary levels of calcium who had also had calcium oxalate kidney stones. As mentioned above, a diet containing a normal amount of calcium but reduced amounts of animal protein and salt protects against stones better than a low-calcium regimen.
Dietary calcium may actually bind the oxalate in foods, preventing it from being absorbed into the blood and excreted into the urine. In a normal healthy diet, dairy products supply almost 80% of the daily calcium requirement. It should be further noted that many people have calcium stones associated with resorption (the breakdown of bone that releases calcium into the bloodstream). Limiting calcium intake in such people could actually promote further bone loss.
Calcium Supplements. Evidence on calcium supplements is mixed, although in general many studies suggest that they reduce oxalate levels and so help prevent calcium oxalate stones. One study suggested that taking 500 mg of calcium supplements a day regularly may "reprogram" the intestines to absorb less calcium and so be protective. Experts generally advise that calcium supplementation within dosage recommendations, approximately 1,200 mg per day, remains safe. In one study, however, women who took calcium supplements had a 20% higher risk for stones. Research indicates that dosages of calcium above 2,000 mg per day are clearly associated with the formation of stones. Some experts speculate that this higher risk may occur because supplements are often taken in the morning, either without food or with breakfast, which is typically low in oxalates. Taking supplements with later meals may not incur the same risk.
Calcium Restriction in Certain Cases. Some calcium stone patients may need to restrict calcium, such as those whose stones are caused by genetic defects in which the intestine over-absorbs calcium. More studies are needed to define this group precisely.
Fiber-Rich Foods and Their Compounds
Fiber may be beneficial for people with kidney stones. In addition, some fiber-rich foods may contain compounds that help protect against kidney stones. A wide variety of high-fiber plant foods contain a compound called phytate (also called inositol hexaphosphate, InsP6, or IP6), which appears to help prevent crystallization of calcium salts, both oxalate and phosphate. Phytate is found in legumes and wheat and rice bran. (Soybeans are also rich in phytate but they are also very high in oxalates, so the overall effects of soy on kidney stones are not clear.)
Purine Restriction in People at Risk for Uric Acid Stones
A high intake of purines can increase the amount of uric acid in the urine, so those at risk for uric acid stones should reduce their intake of foods that contain purines. They include beer and other alcoholic beverages, anchovies, sardines, yeast, organ meats (e.g., liver, kidneys), legumes (e.g., dried beans, peas, and soybeans), mushrooms, spinach, asparagus, cauliflower, and poultry.
Oxalate Restriction in Hyperoxaluria
Most people with calcium oxalate stones should not avoid oxalate-rich foods unless the physician specifically recommends a restrictive diet. Oxalate binds with calcium in the intestine, which may actually reduce calcium absorption. Some studies, in fact, indicate that eating foods containing oxalates and calcium together may reduce the risk of stones. Most of the foods that contain oxalates are very important for good health. Restricting oxalates may be particularly harmful in people with bowel disorders marked by malabsorption.
Role of Fats
Certain fats may play a beneficial or harmful role in specific cases of kidney stones.
Restricted Fats in Patients with Stones Associated with Bowel Disease. Patients who have stones associated with short-bowel syndrome should restrict their intake of fat as well oxalates. In such cases, calcium may bind to unabsorbed fat instead of to oxalates, which increase oxalate levels.
Fish Oil. Some evidence suggests that omega-3 fatty acids, which are found in certain oily fish, may have properties that reduce the risk for calcium stones. Such fatty acids reduce factors that produce inflammation and which may increase the risk for stone production. Omega-3 fatty acids can be obtained in supplements, but their efficacy is not known.
Vitamins in Hyperoxaluria
Vitamin B6. Vitamin B6, or pyridoxine, is used to treat people with primary hyperoxaluria, a severe inherited disorder. Patients should not try to self-medicate with vitamin B6. Very high doses (500 to 2,000 mg daily over long periods) can cause nerve damage with loss of balance and numbness in the feet and hands. Food sources of vitamin B6 include meats, oily fish, poultry, whole grains, dried fortified cereals, soybeans, avocados, baked potatoes with skins, watermelon, plantains, bananas, peanuts, and brewers yeast.
Note on Vitamin C. Ascorbic acid (vitamin C) may convert to oxalates, and people with hyperoxaluria should avoid vitamin C supplements. (A high intake of vitamin C does not appear to increase the risk of stone formation in people with no risk factors for stones.)
Stress Management Techniques
Because of an association between stress and kidney stones, relaxation and stress management techniques may also be beneficial.