The most important treatment is to remove the source of exposure to the offending agent. Reduction of dust levels within the factory by improving machinery or ventilation will help prevent byssinosis. Some people may have to change jobs to avoid further exposure.

Medications such as bronchodilators will usually improve symptoms. Corticosteroids may be prescribed in more severe cases.

Stopping smoking is very important for people with this condition. Respiratory treatments, including nebulizers and postural drainage, may be prescribed if the condition becomes chronic. Home oxygen therapy may also be needed if low blood oxygen levels are detected.

Physical exercise programs, breathing exercises, and patient education programs are often very helpful for people with a chronic lung disease.