• Sudden onset of high fever
• Chills
• General discomfort, uneasiness, or ill feeling (malaise)
• Muscular pains
• Severe headache
• Smooth, oval, reddened, painful swellings of swollen lymph glands called buboes in the groin, armpits, neck, or elsewhere in the body. Pain may occur in the area before the swelling; the most common area is in the groin
• Seizures

• Severe cough
• Frothy, bloody sputum
• Difficulty breathing

SEPTICEMIC PLAGUE

• Fever
• Extreme illness
• Nausea, vomiting, diarrhea, and abdominal pain
• Low blood pressure
• Blood clotting problems
• Failure of several or all organ systems

• Culture of bubo
• Culture of sputum
• Blood culture
• Lymph node culture