|Injury Disease Nutrition Poison Symptoms Surgery Test |
|A B C D E F G H I J K L M N O P Q R S T U V W X Y Z|
Mesangial proliferative glomerulonephritis
|Overview Symptoms Treatment Prevention|
|Mesangial proliferative glomerulonephritis is a kidney disorder characterized by swelling and blood in the urine (dark urine). It is caused by inflammation of an internal kidney structure (glomerulus), and specifically an increase in number of certain glomerular cells (mesangial cells), accompanied by antibody deposits in the mesangium layer of the glomerular capillary.|
|Glomerulonephritis - mesangial proliferative; Mesangial proliferative GN|
|Causes, incidence, and risk factors:|
Mesangial proliferative glomerulonephritis is a form of glomerulonephritis (inflammation of the kidney glomeruli). The mesangial cells (part of the glomerular capillaries) increase in size and number, giving the glomeruli a lumpy appearance.
The mechanism that triggers the disorder is unknown, but it is believed to be some type of immune response, because inflammation of the glomeruli is associated with deposits of antibodies.
It may be seen more commonly in lupus patients who develop GN, and in patients who have IgA mediated kidney disease (see IgA nephropathy). It can affect both adults and children. Men may be affected slightly more often than women.